The aim of this report is to investigate the best possible image quality for high-speed flat-panel detector micro-CT. Specifically, the aim is to investigate the severity of image distortion as a result from the high rotational and acquisition speed. The best possible acquisition mode for high-speed micro-CT is investigated by scanning a (deceased) mouse and investigating the required scan time and resulting image quality. Image degradation due to afterglow and due to the rolling shutter effect are determined by measuring the signal intensity decay profile of the detector and by measuring the angle deformation of a pipe phantom for various speeds.