Purpose: This paper aims to explore, which characteristics of activity-based offices are related to the position of workers on the burnout – engagement continuum. Design/methodology/approach: Literature review and an online survey amongst knowledge workers in the Netherlands, which provided data of 184 respondents from 14 organisations. The data has been analysed by descriptive statistics, bivariate analyses, factor analyses and path analysis, to test the conceptual model. Findings: Five physical work environment constructs were identified of which three showed to have significant relations with employees’ position on one of the three dimensions of the burnout – engagement continuum. Distraction has a direct and indirect (through overload) negative relation with the individual strain (meaning increased exhaustion). Office comfort has indirect positive relations (through recognition and appreciation) with the interpersonal strain (meaning increased involvement). The possibility for teleworking has an indirect positive relation (through control) on the self-evaluation strain (meaning increased efficacy). Practical implications: The findings show that in the design and management of a healthy physical work environment, corporate real estate managers and human resource managers should particularly pay attention to lowering distraction, providing comfortable workplaces and considering the option of teleworking to some extent. Originality/value: This paper provides new insights into the impact of distinct activity-based workplace characteristics on workers’ position on the burnout – engagement continuum.