Geothermal reservoir scaling controlled by reactive flow is a common phenomenon during geothermal development, which might lead to the decline of geothermal productivity and abandonment of geothermal projects. It is significant to reveal chemical influence on the geothermal reservoir characteristics and production performance to provide the reference for geothermal sustainable development. In this work, a thermal-hydraulic-chemical coupling model is developed for a triple-well fractured enhanced geothermal system considering the silica dissolution and precipitation at the fracture surface. It is focused on the evolution of fracture aperture and geothermal productivity. The results indicate that undersaturated injection will cause mineral dissolution which leads to the rise of fracture transmissibility and a thermal break. The fracture width is enhanced by 0.093 mm, and the permeability is 8 times the initial value after 20-year production. The oversaturated injection will cause mineral precipitation which leads to the reduction of fracture aperture and the increase of pressure difference. The opening is reduced by 0.041 mm and the permeability goes down by 2 orders of magnitude. The maximum increases of average production temperature and differential pressure are 10 °C and 13.5 MPa respectively in the 20th year from undersaturation to supersaturation. Besides, it is figured out that reaction rate denotes the evolution of fracture aperture. Both of them are distributed as a band at a fracture plane, which is determined by saturation index and temperature together. The former controls the reaction pattern (dissolution/precipitation) while the latter controls the reaction speed. Furthermore, the evolution of opening is uneven around the production well at different exploitation stages. Fracture width is higher on the strong side in the first 8.7 years but is higher on the weak side in later development when undersaturated water (0 mol/kg) is injected. The phenomenon can be employed to judge the production status, guide the descaling, etc. Production analysis indicates that oversaturation delays the heat breakthrough and undersaturation reduces the surface pump input. This study will provide a significant reference for the geothermal sustainable production influenced by chemical reactions in an enhanced geothermal system.