The present study aims to investigate the relationship between emotions experienced during learning and metacognition in typically developing (TD) children and those with autism spectrum disorder (ASD). This will assist us in using machine learning (ML) to develop a facial emotion recognition (FER) based intelligent tutor system (ITS) to support children’s metacognitive monitoring process in order to enhance their learning outcomes. In this paper, we first report the results of our preliminary research, which utilized an ML-based FER algorithm to detect four spontaneous epistemic emotions (i.e., neutral, confused, frustrated, and boredom) and six spontaneous basic emotions (i.e., anger, disgust, fear, happiness, sadness, and surprise). Subsequently, we adapted an application (‘BrainHood’) to create the ‘Meta-BrainHood’, that embedded our proposed ML-based FER algorithm to examine the relationship between facial emotion expressions and metacognitive monitoring performance in TD children and those with ASD. Finally, we outline the future steps in our research, which adopts the outcomes of the first two steps to construct an ITS to improve children’s metacognitive monitoring performance and learning outcomes.@en