The hydraulic performance and mechanical stability of open fractures are crucial for several subsurface applications including fractured geothermal reservoirs or nuclear waste repositories. Their hydraulic and mechanical properties (fluid flow and fracture stiffness) are both strongly dependent on the fracture geometry. Any change in effective stress impacts aperture and thus the ability of fractures to promote flow. Here, we carried out flow experiments with shear displaced tensile fractures in pre-loaded, low-permeability sandstones with two different cyclic loading scenarios with up to 60 MPa hydrostatic confining pressure. During “constant cyclic loading” (CCL) experiments, the fracture was repeatedly loaded to the same peak stress (up to 60 MPa). During “progressive cyclic loading” (PCL) experiments, the confining pressure was progressively increased in each cycle (up to 15, 30, 45, and 60 MPa). The matrix and fracture deformation was monitored using axial and circumferential LVDT extensometers to obtain the fracture stiffness. The fracture geometry before and after the experiment was compared by calculating the aperture distribution from 3D surface scans. Initial loading with confining pressure of the fracture leads to a linear fracture specific stiffness evolution. For any subsequent stress cycles fracture stiffness shifts to a nonlinear behavior. The transition is shown to be related to a stress memory effect, similar to the “Kaiser Effect” for acoustic emissions. PCL of fractures possibly leads to less permeability reduction compared to continuous cyclic loading.