Throughout history, the human population has experienced major outbreaks of infectious diseases. In December 2019 the previously unknown SARS-CoV-2 virus emerged, which had a huge impact globally. Residents of long- term care facilities (LTCFs) showed to be highly susceptible to infection due to their frailty. Respiratory infectious diseases, such as COVID-19, can spread among others via the airborne transmission route. This is caused by sharing the same indoor environment. To reduce the risk of infection via the airborne route, it is important to consider ventilation and other building services system measures, including personalized ventilation (PV). PV has the potential of being a suitable solution for LTCFs, as it could still allow interaction between residents and visitors in the common rooms, which is regarded very important from a mental health perspective. To identify the potential of PV in the context of infection risk, a laboratory experiment was conducted to investigate its effectiveness on the infection risk reduction. The research was performed in a controlled climate chamber. In the experiment a person was mimicked and positioned close to a PV system that provided filtered recirculated air. A particle source maintained a constant particle concentration in the room. The performance of the PV system was measured through the particle concentration near the breathing zone as compared to the room concentration. Several design parameters were investigated. Translating the outcomes to a fictive (equivalent) ventilation rate, the Wells-Riley equation was applied to determine the infection risk. The outcomes indicated that, in this laboratory setting, the PV system can reduce the risk of an infection up to 50%. The performance is affected by the distance of the supply head to the breathing zone, the angle of the supply head, airflows in the room and the location of the particle source. To further optimize the system and allow its application in LTCFs, several aspects still need further attention, such as mobility/placing the person, the breathing pattern of the user and factors influencing the comfort and use.