Wire and Arc Additive Manufacturing (WAAM) has great potential for efficiently producing large metallic components. However, like other additive manufacturing techniques, materials processed by WAAM exhibit anisotropic properties. Assuming isotropic material properties in design optimization thus leads to less efficient material utilization. Instead of viewing WAAM-induced material anisotropy as a limitation, we consider it an opportunity to improve structural performance. This requires the integration of process planning into structural design. In this paper, we propose a novel method to utilize material anisotropy to enhance the performance of structures both during fabrication and in their use. Our approach is based on space–time topology optimization, which simultaneously optimizes the structural layout and the fabrication sequence. To model material anisotropy in space–time topology optimization, we derive the material deposition direction from the gradient of the pseudo-time field, which encodes the fabrication sequence. Numerical results demonstrate that leveraging material anisotropy effectively improves the performance of intermediate structures during fabrication as well as the overall structure.