The effective environmental management of combined sewer systems requires reliable estimation of discharge and pollutant loads conveyed at the outlet during rainstorms. This study investigates how, with a lumped modelling approach, it is possible to reproduce the quality characteristics of discharged water, provided that high temporal resolution experimental data of pollutant concentrations are available. The methodology is applied to the combined sewer of a real urban drainage network where a continuous high resolution monitoring campaign of water quality and quantity has been carried out at an overflow structure location near the outlet of the drainage system. The lumped modelling approach has been implemented in the Storm Water Management Model (SWMM) with hydrological parameters estimated from cartographic information, based on recently proposed methodology that allows reliably simulating the storm hydrographs without model calibration. A semi-distributed model has been also developed using the SWMM with hydrologic parameters randomly sampled to fit the measured hydrographs of different training and validation data. The results obtained show that the uncalibrated lumped model simulates the observed hydrographs with similar performance as with the semi-distributed model (i.e., the normalized Nash-Sutcliff efficiency index of the validation set is 0.753 for the uncalibrated lumped model and 0.765 for the best-performing sampled parameter set of the semi-distributed model). The water quality parameters describing the build-up and wash-off of total dissolved solids (TDS) in a lumped model have been calibrated too, as well as those describing the mixing and consumption of dissolved oxygen (DO). The results show that a lumped modelling approach can reproduce the water quality dynamics in a combined sewer system, representing a promising tool for effective environmental management. However, event-specific calibrated parameter values have been obtained in some cases, which require further investigation and still limit the general applicability of the obtained results, thus confirming that setting up a reliable model requires water quality measurements.