Aims Despite the fact that the WHO stresses the role of the built environment as key determinant for an autonomous life in wellbeing, architecture and health still are not connected in architectural and medical education and as a result in architectural and medical practice. This paper aims toDespite the fact that the WHO stresses the role of the built environment as key determinant for an autonomous life in wellbeing, architecture and health still are not connected in architectural and medical education and as a result in architectural and medical practice. This paper aims to provide a targeted overview of the theory for the need to educate and create a dialogue between designers, healthcare professionals and entrepreneurs of retirement and chronic facility sector. Theoretical approach The paper puts together the existing architectural thinking such as space syntax, normalization theory, architectural guidelines for dementia, universal design and accessibility theories and juxtaposes them to the cognitive and physical evolution of human needs throughout the lifespan, as expressed by the current medical evidence base. It cherry-picks the elements that each theory could contribute to a fit for purpose design practice that would be in accordance to the recent demographical shift. Conclusions The paper stresses the fact that a more inclusive architecture that is in line with the perception and the physiological needs of the people throughout their lifespan could create domestic, healthcare and public environments that work in synergies with medical and technological interventions through a mechanism of enabling. These solutions could be low cost or even noadding- cost compared to conventional architecture but require a shift in design methodologies of all scales to more evidence-based and inclusive perspectives. provide a targeted overview of the theory for the need to educate and create a dialogue between designers, healthcare professionals and entrepreneurs of retirement and chronic facility sector. Theoretical approach The paper puts together the existing architectural thinking such as space syntax, normalization theory, architectural guidelines for dementia, universal design and accessibility theories and juxtaposes them to the cognitive and physical evolution of human needs throughout the lifespan, as expressed by the current medical evidence base. It cherry-picks the elements that each theory could contribute to a fit for purpose design practice that would be in accordance to the recent demographical shift. Conclusions The paper stresses the fact that a more inclusive architecture that is in line with the perception and the physiological needs of the people throughout their lifespan could create domestic, healthcare and public environments that work in synergies with medical and technological interventions through a mechanism of enabling. These solutions could be low cost or even noadding- cost compared to conventional architecture but require a shift in design methodologies of all scales to more evidence-based and inclusive perspectives.@en