This article presents an integrated educational module for undergraduate traffic engineering at the microscale level. When dealing with a complex transportation system, the education program should cultivate students’ acquisition of both in-depth traffic specialization and breadth of engineering knowledge. For the educational instruction of the signal phase design, this article presents an integrated design that includes several engineering subjects: signal phase design, circuits and electronics, and object-oriented programming (OOP). Due to the lengthy evolution of signal phase design and the high-end industrial standards for this issue, this well-structured problem requires an instructional design to adopt a worked example that integrates varied engineering domains. The integrated design session is intended to deliver education through designing a miniature signal controller while creating an immersive situation and encouraging social teamwork. Feedback from participating students has been positive, indicating the achievement of the planned learning objectives and better mastery of engineering practices.@en

Whether novel risk variants of Alzheimer's disease (AD) identified through genome-wide association studies also influence magnetic resonance imaging-based intermediate phenotypes of AD in the general population is unclear. We studied association of 24 AD risk loci with intracranial volume, total brain volume, hippocampal volume (HV), white matter hyperintensity burden, and brain infarcts in a meta-analysis of genetic association studies from large population-based samples (N= 8175-11,550). In single-SNP based tests, AD risk allele of APOE (rs2075650) was associated with smaller HV (. p= 0.0054) and CD33 (rs3865444) with smaller intracranial volume (. p= 0.0058). In gene-based tests, there was associations of HLA-DRB1 with total brain volume (. p= 0.0006) and BIN1 with HV (. p= 0.00089). Aweighted AD genetic risk score was associated with smaller HV (beta ± SE=-0.047 ± 0.013, p= 0.00041), even after excluding the APOE locus (. p= 0.029). However, only association of AD genetic risk score with HV, including APOE, was significant after multiple testing correction (including number of independent phenotypes tested). These results suggest that novel AD genetic risk variants may contribute to structural brain aging in nondemented older community persons.@en