This thesis focuses on the design, prototyping, and testing of a single-use bistable microneedle applicator that is optimized for consistent, and user-friendly skin penetration. The applicator integrates a bistable dome mechanism which is designed to deliver a certain value of force after stretching the skin. Design criteria—manufacturability, user-friendliness, durability, and cost— help the selection process through lots of concepts. Polypropylene (PP) and Polyamide 12 (PA12) are chosen for prototyping. However, the final production material is not the same type of PP as it is used for the prototypes. These models are made by using 3D printing, and are analyzed by finite element simulations in ANSYS to evaluate force-displacement responses and bistable behavior. Experimental testing is done to validate the simulations. However, differences appear that are caused by various reasons such as limitations on 3D printing and testing method, applying boundary conditions, and ....