Accurate detection of vascular occlusions during endovascular thrombectomy (EVT) is critical in acute ischemic stroke (AIS). Interpretation of digital subtraction angiography (DSA) sequences poses challenges due to anatomical complexity and time constraints. This work proposes OccluNet, a spatio-temporal deep learning model that integrates YOLOX, a single-stage object detector, with transformer-based temporal attention mechanisms to automate occlusion detection in DSA sequences. We compared OccluNet with a YOLOv11 baseline trained on either individual DSA frames or minimum intensity projections. Two spatio-temporal variants were explored for OccluNet: pure temporal attention and divided space-time attention. Evaluation on DSA images from the MR CLEAN Registry revealed the model’s capability to capture temporally consistent features, achieving precision and recall of 89.02% and 74.87%, respectively. OccluNet significantly outperformed the baseline models, and both attention variants attained similar performance. Source code is available here.