Baseball pitching is a movement wherein an external valgus moment around the elbow joint regularly causes an ulnar collateral ligament (UCL) injury. A proven relationship between the muscle activation around the elbow joint and its capacity to compensate for the external valgus moment during a baseball pitch allows predicting the likelihood of a UCL injury within pitchers in the future. The present study establishes the generic muscle activity around the elbow joint during a fastball baseball pitch to investigate the capacity of the muscles to compensate for the external valgus moment actively and thereby prevent a UCL injury. Six uninjured, experienced recreational adult pitchers, participated in this study (age: 25 ± 2 years; body height: 188 ± 10 cm; body mass: 77 ± 15 kg). 2000 Hz surface ElectroMyoGraphy (sEMG) was used to measure the muscle activity around the elbow joint in 15 fastball pitches for each participant. Before the pitch measurement, participants had to perform maximum voluntary contractions (MVC). The signals were corrected to an electromechanical delay of 50 ms and normalized to either MVC, or to the maximum of the signal itself. After that, the mean values were calculated for the instance of foot contact, maximum external rotation and ball release separately over the participants. A repeated measures ANOVA was performed to observe whether the mean activity is significantly higher at maximum external rotation compared to the moment of foot contact and ball release to compensate for the peak external valgus moment. Significant peak activity was found at maximum external rotation for all muscles, compared to the instance of ball release. The parallel activity of the flexor pronator mass and m. pronator teres at maximum external rotation enhances a compensating effect to the external valgus moment by its directly counteracting tension. Furthermore, the results support a co-contraction between the flexor pronator mass:extensor supinator mass and m. triceps lateral head: m. biceps brachii muscle pairs to compensate for the external valgus moment by a compression force to the elbow joint. The generic function of the m. anconeus in the fastball baseball pitch is still debated due to the inconsistent results over the different pitchers in this study. This study provides evidence that the muscles around the elbow joint can compensate for the external valgus moment during a fastball pitch. These results provide possibilities for using sEMG to assess the muscle activation pattern of individual pitchers as support to predict and prevent UCL injuries in pitchers in the future.