The Tibetan Plateau is undergoing east-west extension manifested by north-trending rifts. Rift dynamics have been attributed to both mantle convection, which induces vertical motion causing general extension, and plate convergence, with northward motion causing along-strike extension, driven by the subducted Indian slab. However, the cause of lithospheric extension remains debated. We carried out electrical resistivity modeling of the entire Tibetan Plateau and present a quantitative interpretation of low-resistivity structures in terms of high fluid fraction and low viscosity. The model reveals low-resistivity features intruding and overlying the resistive lithosphere of Lhasa and Qiangtang. The low-resistivity features show a transition from vertically oriented to horizontally oriented positions at ∼50−70 km depth and appear to be oriented north-south below the Himalaya and Lhasa and east-west below Qiangtang. The anomalies can be explained by partial melts and fluids and may represent the signatures of material migration and locally weakened lithosphere. This material migration must have been significant enough to sustain rifting and drive the rift tips northward, despite the complex tectonic setting of the Tibetan Plateau, which is composed of a number of independent blocks. The results suggest that north-trending rifts were formed in response to fluid flow, after or during lithospheric foundering below Lhasa. Furthermore, fluid flow can explain the surface distribution of rifts in bands and the variations in rift formation and development between Qiangtang and Lhasa, which are attributed to the local rheological differences and specific regimes of vertical and/or horizontal stresses that are induced by fluid migration.