Titanium and its alloys are usually bonded together using a high temperature resistant polyimide or epoxy adhesives. Such adhesives can withstand temperatures from 200°C to300°C. Earlier research work indicates that Surface modification of titanium with mechanical treatment and atmospheric pressure plasma treatment techniques leads to improved adhesive bond strength of polyimide with titanium at room temperature. In this investigation, durability of these improved adhesive bond strength titanium samples is studied at elevated temperature and moisture level. Samples were exposed at 80°C and 60% Relative humidity conditions in moisture oven. Another set of samples was placed in heating oven at 80°C for dry aging of samples. After conditioning these samples were subjected to single lap shear tensile test. Combined effect of relatively high temperature and moisture on bond strength of titanium samples and only high temperature dry aged samples are studied. Single lap shear tensile test results indicate that conditioning at high temperature and moisture resulted in significant decrease of adhesive bond strength, where as dry aging at same temperature has no effect on adhesive bond strength. A comparison of the bond strength of these elevated condition samples and normal room condition samples will be presented in this paper.