The study of hydraulic head changes over time is a common task for groundwater hydrologists. Groundwater signatures are numerical metrics, or statistical aggregates, that quantify the behavior observed in hydraulic head hydrographs. Signatures can be helpful in a number of classical hydrological tasks, such as hydrograph classification, clustering, change detection, and model evaluation, selection, and calibration. Despite the potential benefits of using signatures in groundwater studies, their application has not yet been thoroughly explored. To support research into the application of signatures in groundwater studies, we introduce the new groundwater signatures module from the Pastas software. The signatures module is written in Python, fully tested and documented, and available as open-source software under the MIT license. In this paper, it is shown how the signatures are tested and can be used in practical applications through two examples. In the first example, signatures are used to characterize and cluster monitoring wells in a nationwide monitoring network in Switzerland. In the second example, signatures are used to evaluate how well different groundwater model structures simulate the heads. Future research opportunities involving groundwater signatures are discussed.