HP
Hilleke E Hulshoff Pol
info
Please Note
<p>This page displays the records of the person named above and is not linked to a unique person identifier. This record may need to be merged to a profile.</p>
2 records found
1
Journal article
(2019)
-
Jalmar Teeuw, Rachel M. Brouwer, João P.O.F.T. Guimarães, Philip Brandner, Marinka M.G. Koenis, Suzanne C. Swagerman, Maxime Verwoert, Dorret I. Boomsma, Hilleke E. Hulshoff Pol
The human brain is active during rest and hierarchically organized into intrinsic functional networks. These functional networks are largely established early in development, with reports of a shift from a local to more distributed organization during childhood and adolescence. It remains unknown to what extent genetic and environmental influences on functional connectivity change throughout adolescent development. We measured functional connectivity within and between eight cortical networks in a longitudinal resting-state fMRI study of adolescent twins and their older siblings on two occasions (mean ages 13 and 18 years). We modelled the reliability for these inherently noisy and head-motion sensitive measurements by analyzing data from split-half sessions. Functional connectivity between resting-state networks decreased with age whereas functional connectivity within resting-state networks generally increased with age, independent of general cognitive functioning. Sex effects were sparse, with stronger functional connectivity in the default mode network for girls compared to boys, and stronger functional connectivity in the salience network for boys compared to girls. Heritability explained up to 53% of the variation in functional connectivity within and between resting-state networks, and common environment explained up to 33%. Genetic influences on functional connectivity remained stable during adolescent development. In conclusion, longitudinal age-related changes in functional connectivity within and between cortical resting-state networks are subtle but wide-spread throughout adolescence. Genes play a considerable role in explaining individual variation in functional connectivity with mostly stable influences throughout adolescence.
...
The human brain is active during rest and hierarchically organized into intrinsic functional networks. These functional networks are largely established early in development, with reports of a shift from a local to more distributed organization during childhood and adolescence. It remains unknown to what extent genetic and environmental influences on functional connectivity change throughout adolescent development. We measured functional connectivity within and between eight cortical networks in a longitudinal resting-state fMRI study of adolescent twins and their older siblings on two occasions (mean ages 13 and 18 years). We modelled the reliability for these inherently noisy and head-motion sensitive measurements by analyzing data from split-half sessions. Functional connectivity between resting-state networks decreased with age whereas functional connectivity within resting-state networks generally increased with age, independent of general cognitive functioning. Sex effects were sparse, with stronger functional connectivity in the default mode network for girls compared to boys, and stronger functional connectivity in the salience network for boys compared to girls. Heritability explained up to 53% of the variation in functional connectivity within and between resting-state networks, and common environment explained up to 33%. Genetic influences on functional connectivity remained stable during adolescent development. In conclusion, longitudinal age-related changes in functional connectivity within and between cortical resting-state networks are subtle but wide-spread throughout adolescence. Genes play a considerable role in explaining individual variation in functional connectivity with mostly stable influences throughout adolescence.
Journal article
(2016)
-
Hieab H H Adams, Derrek P. Hibar, Ashley H. Beecham, Lianne Schmaal, Andrew J. Schork, Li Shen, Jean Shin, Elena Shumskaya, Albert V. Smith, Emma Sprooten, Lachlan T. Strike, Alexander Teumer, Russell Thomson, Neda Jahanshad, Diana Tordesillas-Gutierrez, Roberto Toro, Daniah Trabzuni, Dhananjay Vaidya, Jeroen Van Der Grond, Dennis Van Der Meer, Marjolein M J Van Donkelaar, Kristel R. Van Eijk, Theo G M Van Erp, Daan Van Rooij, Katharina Wittfeld, Esther Walton, Lars T. Westlye, Christopher D. Whelan, Beverly G. Windham, Anderson M. Winkler, Girma Woldehawariat, Christiane Wolf, Thomas Wolfers, Bing Xu, Lisa R. Yanek, Sven J. Van Der Lee, Jingyun Yang, Alex Zijdenbos, Marcel P. Zwiers, Ingrid Agartz, Neelum T. Aggarwal, Laura Almasy, David Ames, Philippe Amouyel, Ole A. Andreassen, Sampath Arepalli, Lucija Abramovic, Amelia A. Assareh, Sandra Barral, Mark E. Bastin, Diane M. Becker, James T. Becker, David A. Bennett, John Blangero, Hans Van Bokhoven, Dorret I. Boomsma, Henry Brodaty, Saud Alhusaini, Rachel M. Brouwer, Han G. Brunner, Randy L. Buckner, Jan K. Buitelaar, Kazima B. Bulayeva, Wiepke Cahn, Vince D. Calhoun, Dara M. Cannon, Gianpiero L. Cavalleri, Christopher Chen, Najaf Amin, Ching Yu Cheng, Sven Cichon, Mark R. Cookson, Aiden Corvin, Benedicto Crespo-Facorro, Joanne E. Curran, Michael Czisch, Anders M. Dale, Gareth E. Davies, Eco J C De Geus, Micael Andersson, Philip L. De Jager, Greig I. De Zubicaray, Norman Delanty, Chantal Depondt, Anita L. Destefano, Allissa Dillman, Srdjan Djurovic, Gary Donohoe, Wayne C. Drevets, Ravi Duggirala, Konstantinos Arfanakis, Thomas D. Dyer, Susanne Erk, Thomas Espeseth, Denis A. Evans, Iryna O. Fedko, Guillén Fernández, Luigi Ferrucci, Simon E. Fisher, Debra A. Fleischman, Ian Ford, Benjamin S. Aribisala, Tatiana M. Foroud, Peter T. Fox, Clyde Francks, Masaki Fukunaga, J. Raphael Gibbs, David C. Glahn, Randy L. Gollub, Harald H H Göring, Hans J. Grabe, Robert C. Green, Vincent Chouraki, Nicola J. Armstrong, Oliver Gruber, Vilmundur Gudnason, Sebastian Guelfi, Narelle K. Hansell, John Hardy, Catharina A. Hartman, Ryota Hashimoto, Katrin Hegenscheid, Andreas Heinz, Stephanie Le Hellard, Lavinia Athanasiu, Dena G. Hernandez, Dirk J. Heslenfeld, Beng Choon Ho, Pieter J. Hoekstra, Wolfgang Hoffmann, Albert Hofman, Florian Holsboer, Georg Homuth, Norbert Hosten, Jouke Jan Hottenga, Tomas Axelsson, Hilleke E Hulshoff Pol, Masashi Ikeda, M. Kamran Ikram, Clifford R. Jack, Mark Jenkinson, Robert Johnson, Erik G. Jönsson, J. Wouter Jukema, René S. Kahn, Derek W. Morris, Alexa Beiser, Wiro J. Niessen, More Authors..., Manon Bernard, Joshua C. Bis, Laura M E Blanken, Susan H. Blanton, Marc M. Bohlken, Marco P. Boks, Jason L. Stein, Janita Bralten, Adam M. Brickman, Owen Carmichael, M. Mallar Chakravarty, Ganesh Chauhan, Qiang Chen, Christopher R K Ching, Gabriel Cuellar-Partida, Anouk Den Braber, Nhat Trung Doan, Paul A. Nyquist, Stefan Ehrlich, Irina Filippi, Tian Ge, Sudheer Giddaluru, Aaron L. Goldman, Rebecca F. Gottesman, Corina U. Greven, Oliver Grimm, Michael E. Griswold, Tulio Guadalupe, Miguel E. Rentería, Johanna Hass, Unn K. Haukvik, Saima Hilal, Edith Hofer, David Hoehn, Avram J. Holmes, Martine Hoogman, Deborah Janowitz, Tianye Jia, Dalia Kasperaviciute, Stella Trompet, Sungeun Kim, Marieke Klein, Bernd Kraemer, Phil H. Lee, Jiemin Liao, David C M Liewald, Lorna M. Lopez, Michelle Luciano, Christine Macare, Andre Marquand, Alejandro Arias-Vasquez, Mar Matarin, Karen A. Mather, Manuel Mattheisen, Bernard Mazoyer, David R. McKay, Rebekah McWhirter, Yuri Milaneschi, Nazanin Mirza-Schreiber, Ryan L. Muetzel, Susana Muñoz Maniega, Sudha Seshadri, Kwangsik Nho, Allison C. Nugent, Loes M Olde Loohuis, Jaap Oosterlaan, Martina Papmeyer, Irene Pappa, Lukas Pirpamer, Sara Pudas, Benno Pütz, Kumar B. Rajan, Sylvane Desrivières, Adaikalavan Ramasamy, Jennifer S. Richards, Shannon L. Risacher, Roberto Roiz-Santiañez, Nanda Rommelse, Emma J. Rose, Natalie A. Royle, Tatjana Rundek, Philipp G. Sämann, Claudia L. Satizabal
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (genetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (N combined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits.
...
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (genetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (N combined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits.