Increasing congestion and environmental pressures in urban logistics, alongside growing population demands, necessitate innovative solutions. This thesis tackles synchronized two-echelon routing problems within multimodal logistics, specifically exploring the potential of integrating waterborne transport. By developing optimization models and solution approaches for the comprehensive design and management of these systems—encompassing strategic location, tactical allocation, and operational routing and synchronization—the results promote a transition toward more sustainable and efficient urban logistics, ultimately fostering healthier, more livable, and economically vibrant cities.