In vitro and in silico modeling of endovascular stroke treatments for acute ischemic stroke

Review (2021)

Authors

G. Luraghi Medical Instruments & Bio-Inspired Technology - Mechanical, Maritime and Materials Engineering , Politecnico di Milano
R.M.E. Cahalane Erasmus MC
Emma van de Ven Student
F.J.H. Gijsen Medical Instruments & Bio-Inspired Technology - Mechanical, Maritime and Materials Engineering , Erasmus MC
A.C. Akyildiz Medical Instruments & Bio-Inspired Technology - Mechanical, Maritime and Materials Engineering , Erasmus MC
Research Group
Medical Instruments & Bio-Inspired Technology (Mechanical, Maritime and Materials Engineering) (TU Delft)
Acute ischemic stroke Aspiration Stent-retriever Thrombectomy
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Published Date

2021

Language

English

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Faculty

Mechanical, Maritime and Materials Engineering

Department

Biomechanical Engineering

Research Group

Medical Instruments & Bio-Inspired Technology

Abstract

Acute ischemic stroke occurs when a thrombus obstructs a cerebral artery, leading to sub-optimal blood perfusion to brain tissue. A recently developed, preventive treatment is the endovascular stroke treatment (EVT), which is a minimally invasive procedure, involving the use of stent-retrievers and/or aspiration catheters. Despite its increasing use, many critical factors of EVT are not well understood. In this respect, in vitro, and in silico studies have the great potential to help us deepen our understanding of the procedure, perform further device and procedural optimization, and help in clinical training. This review paper provides an overview of the previous in vitro and in silico evaluations of EVT treatments, with a special emphasis on the four main aspects of the adopted experimental and numerical set-ups: vessel, thrombus, device, and procedural settings.