Optimizing MNP injection for magnetic hyperthermia treatment
A three-dimensional study
Qian Jiang (The Hong Kong Polytechnic University)
Zhaokun Wang (The Hong Kong Polytechnic University)
Feng Ren (Northwestern Polytechnical University)
Chenglei Wang (Institute of High Performance Computing)
Gholamreza Kefayati (University of Tasmania)
Sasa Kenjeres (TU Delft - Applied Sciences)
Kambiz Vafai (University of California)
Xinguang Cui (Huazhong University of Science and Technology)
Yang Liu (The Hong Kong Polytechnic University)
Hui Tang (The Hong Kong Polytechnic University)
More Info
expand_more
Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.
Abstract
This work investigates optimal magnetic nanoparticle (MNP) injection strategies in three-dimensional (3D) tumor models to enhance the magnetic hyperthermia efficacy. We consider three tumor models with increasing geometric complexities: a spherical tumor, a simple irregular tumor (two connected spheres of different sizes), and a complex irregular tumor (three connected spheres of varying sizes). Centrosymmetric MNP distributions are employed for the spherical model, whereas asymmetric distributions are applied for the irregular models. The rapid convergence of the optimization demonstrates the efficiency and effectiveness of this 3D optimization framework. For the spherical tumor model, multi-site injections significantly enhance therapeutic outcomes under a 20-min waiting limit, whereas a single-site injection with a 114.9-min waiting time achieves 100% tumor ablation without damaging adjacent healthy tissue. Two injection sites suffice for the simple irregular tumor model, while a three-site strategy is optimal for the complex irregular model, indicating a relationship between required injection number and tumor geometry. Furthermore, the optimal MNP injection strategies correlate positively with the locations and sizes of the connected spheres. These findings produce more practical optimal strategies and provide broader, clinically relevant guidance for magnetic hyperthermia treatment.
help_outline