Modelling the immune system response to epithelial wound infections

Journal article (2016)

Authors

F.J. Vermolen Numerical Analysis - EEMCS
L. Arkesteijn Rivers, Ports, Waterways and Dredging Engineering - CEG
A Gefen Tel Aviv University
Research Group
Numerical Analysis (EEMCS) (TU Delft)
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Published Date

2016

Language

English

Reuse Rights

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Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Delft Institute of Applied Mathematics

Research Group

Numerical Analysis

Abstract

In this paper, a cell-colony based formalism for the healing of superficial wounds is presented. The paper incorporates the migration, proliferation, and death of constituent cells, in the context of wound healing. The present study considers wound healing under ischemic conditions where a bacterial infection develops, which impairs the motility of the constituent cells. In this work, the performance of the immune response system is incorporated in the sense that migrating leukocyte are modelled which engulf the infectious pathogens. The model is based on both deterministic and stochastic principles. Simulation results are discussed in a biological context.