Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

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Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

Journal Article (2017)

Author(s)

L. Schmaal (Amsterdam UMC)

D. P. Hibar (Keck School of Medicine of USC)

Philipp G. Sämann (Max Planck Institute of Psychiatry)

G. B. Hall (McMaster University)

B. T. Baune (University of Adelaide)

N. Jahanshad (Keck School of Medicine of USC)

J. W. Cheung (Keck School of Medicine of USC)

T. G M Van Erp (University of California)

D. Bos (Erasmus MC)

Mohammad A. Ikram (Erasmus MC)

Meike W. Vernooij (Erasmus MC)

W. J. Niessen (TU Delft - ImPhys/Quantitative Imaging, Erasmus MC)

H Tiemeier (Erasmus MC)

A Hofman (Erasmus MC)

K. Wittfeld (German Center for Neurodegenerative Diseases (DZNE))

H. J. Grabe (University Medicine Greifswald, German Center for Neurodegenerative Diseases (DZNE))

Deborah Janowitz (University Medicine Greifswald)

R. Bülow (University Medicine Greifswald)

M. Selonke (University Medicine Greifswald)

Henry Völzke (University Medicine Greifswald, Partner site Griefswald)

D. Grotegerd (Universität Münster)

U. Dannlowski (Universität Münster, Philipps-University Marburg)

V. Arolt (Universität Münster)

N. Opel (Universität Münster)

W. Heindel (Universität Münster)

H Kugel (Universität Münster)

D. Hoehn (Neuroimaging Research Group)

M. Czisch (Neuroimaging Research Group)

B. Couvy-Duchesne (University of Queensland, Queensland Institute of Medical Research)

Miguel E. Rentería (Queensland Institute of Medical Research)

L. T. Strike (University of Queensland)

M. J. Wright (University of Queensland)

N. T. Mills (Queensland Institute of Medical Research, University of Queensland)

G. I. De Zubicaray (Queensland University of Technology)

K. L. McMahon (University of Queensland)

S. E. Medland (Queensland Institute of Medical Research)

Nicholas G. Martin (Queensland Institute of Medical Research)

N. A. Gillespie (Virginia Institute for Psychiatric and Behavioral Genetics)

R. Goya-Maldonado (University of Göttingen)

O. Gruber (Heidelberg University Hospital)

B. Krämer (Heidelberg University Hospital)

S. N. Hatton (University of Sydney)

J. Lagopoulos (University of Sydney)

I. B. Hickie (University of Sydney)

T. Frodl (Trinity College Dublin, Otto-von-Guericke University)

A. Carballedo (Trinity College Dublin)

E. M. Frey (Universität Regensburg)

L. S. Van Velzen (Amsterdam UMC)

B. W J H Penninx (Amsterdam UMC)

M. J. Van Tol (Rijksuniversiteit Groningen)

N. J. Van Der Wee (Leiden University Medical Center)

C. G. Davey (University of Melbourne, Orygen)

B. J. Harrison (University of Melbourne, Melbourne Neuropsychiatry Centre)

B. Mwangi (University of Texas Health Science Center at Houston)

B. Cao (University of Texas Health Science Center at Houston)

J. C. Soares (University of Texas Health Science Center at Houston)

I. M. Veer (Charité Universittsmedizin Berlin)

H Walter (Charité Universittsmedizin Berlin)

D. Schoepf (Universität Bonn)

B. Zurowski (University of Lübeck)

C. Konrad (Philipps-University Marburg, Agaplesion Diakonieklinikum Rotenburg)

E Schramm (University Medical Center Freiburg)

C. Normann (University Medical Center Freiburg)

K. Schnell (Heidelberg University Hospital)

M. D. Sacchet (Stanford University)

I. H. Gotlib (Stanford University)

G. M. MacQueen (University of Calgary)

B. R. Godlewska (University of Oxford)

T. Nickson (The University of Edinburgh)

A. M. McIntosh (The University of Edinburgh)

Martina Papmeyer (The University of Edinburgh, University of Bern)

H. C. Whalley (The University of Edinburgh)

J Hall (The University of Edinburgh, Cardiff University)

J. E. Sussmann (The University of Edinburgh, NHS Borders)

M. Li (Leibniz Institute for Neurobiology)

MT Walter (Leibniz Institute for Neurobiology, Eberhard Karls Universität Tübingen)

L. Aftanas (Scientific Research Institute of Physiology and Basic Medicine)

I. Brack (Scientific Research Institute of Physiology and Basic Medicine)

N. A. Bokhan (Siberian State Medical University, National Research Tomsk State University, Russian Academy of Sciences)

P. M. Thompson (Keck School of Medicine of USC)

D. J. Veltman (Amsterdam UMC)

Research Group

ImPhys/Quantitative Imaging

DOI related publication

https://doi.org/10.1038/mp.2016.60 Final published version

To reference this document use

https://resolver.tudelft.nl/uuid:2177462d-4f4d-45de-8d95-081453908395

More Info

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Publication Year

2017

Language

English

Research Group

ImPhys/Quantitative Imaging

Journal title

Molecular Psychiatry

Issue number

6

Volume number

22

Pages (from-to)

900-909

Downloads counter

747

Abstract

The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world. To detect consistent effects of MDD and its modulators on cortical thickness and surface area estimates derived from MRI, statistical effects from sites were meta-analysed separately for adults and adolescents. Adults with MDD had thinner cortical gray matter than controls in the orbitofrontal cortex (OFC), anterior and posterior cingulate, insula and temporal lobes (Cohen's d effect sizes: -0.10 to -0.14). These effects were most pronounced in first episode and adult-onset patients (>21 years). Compared to matched controls, adolescents with MDD had lower total surface area (but no differences in cortical thickness) and regional reductions in frontal regions (medial OFC and superior frontal gyrus) and primary and higher-order visual, somatosensory and motor areas (d: -0.26 to -0.57). The strongest effects were found in recurrent adolescent patients. This highly powered global effort to identify consistent brain abnormalities showed widespread cortical alterations in MDD patients as compared to controls and suggests that MDD may impact brain structure in a highly dynamic way, with different patterns of alterations at different stages of life.