Library
local_library Home Repository

A cerium-based metal-organic framework as adsorbent for the 99Mo/99mTc generator

Journal Article (2022)
Author(s)

Chao Ma (TU Delft - RST/Applied Radiation & Isotopes)

Humbert T. Wolterbeek (TU Delft - RST/Applied Radiation & Isotopes)

A. G. Denkova (TU Delft - RST/Applied Radiation & Isotopes)

P Serra-Crespo (TU Delft - RST/Applied Radiation & Isotopes)

Research Group
RST/Applied Radiation & Isotopes
Copyright
© 2022 C. Ma, H.T. Wolterbeek, A.G. Denkova, P. Serra Crespo
DOI related publication
https://doi.org/10.1016/j.seppur.2022.121218
More Info
expand_more
Publication Year
2022
Language
English
Copyright
© 2022 C. Ma, H.T. Wolterbeek, A.G. Denkova, P. Serra Crespo
Research Group
RST/Applied Radiation & Isotopes
Volume number
295
Reuse Rights

Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.

Abstract

The cerium-based metal–organic framework UiO-66 (Ce) was examined as a potential adsorbent for the 99Mo/99mTc generator. The results showed that the adsorbent had an outstanding adsorption performance, reaching up to 475 mg/g adsorption capacity at pH 3. An adsorption mechanism was proposed, where the adsorption was governed by hydrogen bonds, Ce-O-Mo coordination, π-anions and electrostatic interaction. Additionally, the adsorbent exhibited excellent radiation stability and good adsorption performance when radioactive 99Mo was applied. A 99Mo/99mTc generator was fabricated with UiO-66 (Ce) as adsorbent and its performance was evaluated over two weeks. The elution results showed that 92 ± 3% of 99mTc elution efficiency could be obtained with negligible cerium breakthrough, showing the great potential of UiO-66 (Ce) as adsorbent for 99Mo/99mTc generators.