Chemoenzymatic Halocyclization of γ,δ-Unsaturated Carboxylic Acids and Alcohols
Sabry H.H. Younes (Sohag University, TU Delft - BT/Biocatalysis)
Florian Tieves (TU Delft - BT/Biocatalysis)
Dongming Lan (South China University of Technology)
Yonghua Wang (South China University of Technology)
Philipp Süss (Enzymicals AG, Greifswald)
Henrike Brundiek (Enzymicals AG, Greifswald)
Ron Wever (Van ’t Hoff Institute of Molecular Sciences)
Frank Hollmann (TU Delft - BT/Biocatalysis)
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Abstract
A chemoenzymatic method for the halocyclization of unsaturated alcohols and acids by using the robust V-dependent chloroperoxidase from Curvularia inaequalis (CiVCPO) as catalyst has been developed for the in situ generation of hypohalites. A broad range of halolactones and cyclic haloethers are formed with excellent performance of the biocatalyst.