Chemoenzymatic Halocyclization of γ,δ-Unsaturated Carboxylic Acids and Alcohols

Journal article (2019)

Authors

S.H.H. Younes Sohag University, BT/Biocatalysis - AS
F. Tieves BT/Biocatalysis - AS
Dongming Lan South China University of Technology
Yonghua Wang South China University of Technology
Philipp Süss Enzymicals AG, Greifswald
Henrike Brundiek Enzymicals AG, Greifswald
Ron Wever Van ’t Hoff Institute of Molecular Sciences
F. Hollmann BT/Biocatalysis - AS
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2019 S.H.H. Younes, F. Tieves, Dongming Lan, Yonghua Wang, Philipp Süss, Henrike Brundiek, Ron Wever, F. Hollmann
DOI: https://doi.org/10.1002/cssc.201902240
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Published Date

2019

Language

English

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Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

A chemoenzymatic method for the halocyclization of unsaturated alcohols and acids by using the robust V-dependent chloroperoxidase from Curvularia inaequalis (CiVCPO) as catalyst has been developed for the in situ generation of hypohalites. A broad range of halolactones and cyclic haloethers are formed with excellent performance of the biocatalyst.