Selective oxyfunctionalisation reactions catalysed by P450 monooxygenases and peroxygenases – A bright future for sustainable chemical synthesis
Xiaomin Xu (TU Delft - BT/Biocatalysis)
Thomas Hilberath (TU Delft - BT/Biocatalysis)
Frank Hollmann (TU Delft - BT/Biocatalysis)
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Abstract
Heme-dependent oxygenases (i.e. P450 monooxygenases and peroxygenases) are highly selective catalysts for the selective oxyfunctionalisation or organic compounds. Both enzyme classes exhibit mechanistic similarities (i.e. using so-called compound I (CpdI) as active oxidation species) and differences in how CpdI is formed. From the differences also practical differences arise which may influence the scalability, economic attractiveness and environmental impact of P450 monooxygenase- or peroxygenase-catalysed reactions. In this contribution we propose a range of performance indicators to compare the potential of both enzyme classes.
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