Design of a mechanical loading device for studying the load dependent transport of solutes across articular cartilage in a micro-CT chamber

Master thesis (2014)

Authors

Contributors

H.H. Weinans (mentor)
Programme
BME (Mechanical, Maritime and Materials Engineering) (TU Delft)
Copyright: © 2014 Glynou, A.
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Published Date

23-10-2014

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Programme

BME

Abstract

The present project focused on the design and development of a mechanical loading device that allows the convection studies in cartilage within a micro-CT chamber. A plastic-made device was designed and build in order to ensure the successful operation in the micro-CT. Besides that it allowed the monitoring of the tissue material properties by incorporating a load cell. The later experimental procedure indicated that 10% compression seems to have a beneficial effect on the solutes penetration across articular cartilage. Therefore a clinically applicable tool was developed that includes the convection in a diagnostic method for the first time