High Frame Rate Volumetric Imaging of Microbubbles Using a Sparse Array and Spatial Coherence Beamforming
Luxi Wei (Erasmus MC)
Geraldi Wahyulaksana (Erasmus MC)
Bram Meijlink (Erasmus MC)
Alessandro Ramalli (University of Florence)
Emile Noothout (TU Delft - ImPhys/Medical Imaging)
Martin Verweij (TU Delft - ImPhys/Medical Imaging)
Antonius F.W. Van der Steen (Erasmus MC, TU Delft - ImPhys/Medical Imaging)
Nico De Jong (Erasmus MC, TU Delft - ImPhys/Medical Imaging)
Hendrik J. Vos (Erasmus MC, TU Delft - ImPhys/Medical Imaging)
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Abstract
Volumetric ultrasound imaging of blood flow with microbubbles enables a more complete visualization of the microvasculature. Sparse arrays are ideal candidates to perform volumetric imaging at reduced manufacturing complexity and cable count. However, due to the small number of transducer elements, sparse arrays often come with high clutter levels, especially when wide beams are transmitted to increase the frame rate. In this study, we demonstrate with a prototype sparse array probe and a diverging wave transmission strategy, that a uniform transmission field can be achieved. With the implementation of a spatial coherence beamformer, the background clutter signal can be effectively suppressed, leading to a signal to background ratio improvement of 25 dB. With this approach, we demonstrate the volumetric visualization of single microbubbles in a tissue-mimicking phantom as well as vasculature mapping in a live chicken embryo chorioallantoic membrane.
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