Synthesis of Enantiopure Vicinal Halohydrins Using a Sequence of Haloperoxidase and Lipase
Elisa De Marchi (Universita degli Studi della Tuscia Viterbo)
T. Hilberath (TU Delft - BT/Biocatalysis)
Claudio Zippilli (Universita degli Studi della Tuscia Viterbo)
Ron Wever (Universiteit van Amsterdam)
Raffaele Saladino (Universita degli Studi della Tuscia Viterbo)
F. Hollmann (TU Delft - BT/Biocatalysis)
Lorenzo Botta (Universita degli Studi della Tuscia Viterbo)
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Abstract
Vicinal halohydrins are key building blocks to produce bioactive molecules and drugs, especially if they can be obtained in enantiomerically pure form. In this study, we present a bi-enzymatic sequence that allows to obtain vic-halohydrins through a photochemoenzymatic olefin hydroxy halogenation followed by a lipase catalysed kinetic resolution. The absolute configuration of the resulting products was determined using Mosher's method.
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