Lanthanide-doped NaYF<sub>4</sub> near-infrared-II nanothermometers for deep tissue temperature sensing

Journal article (2022)

Authors

Xiangyang Yuan Southwest University, Chongqing
Endian Cui Southwest University
K. Liu ChemE/Materials for Energy Conversion and Storage - AS
Ying Jiang Southwest University
Xiaoyan Yang Southwest University
Lu Yang Southwest University
Xiaoling Liao Southwest University
Yanan Zhao Southwest University
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Research Group
ChemE/Materials for Energy Conversion and Storage (AS) (TU Delft)
Copyright: © 2022 Xiangyang Yuan, Endian Cui, K. Liu, Ying Jiang, Xiaoyan Yang, Jianfeng Tang, Lu Yang, Xiaoling Liao, Yanan Zhao, More Authors
DOI
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https://doi.org/10.1016/j.ceramint.2022.08.110
Biocompatibility Energy transfer Lanthanide-doped Nanothermometers Second near-infrared region
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Published Date

2022

Language

English

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Faculty

Applied Sciences

Department

ChemE/Chemical Engineering

Research Group

ChemE/Materials for Energy Conversion and Storage

Abstract

In this work, different lanthanides (Tm3+, Er3+; Yb3+, Ho3+, Nd3+) were doped into NaYF4 via a high-temperature coprecipitation method, and followed by SiO2 coating to improve the water dispersibility, resulting in NaYF4:Tm3+, Er3+@NaYF4@SiO2 and NaYF4:Yb3+, Ho3+@NaYF4:Nd3+@SiO2 nanoparticles (NPs). The two NPs both exhibited the temperature-dependent second near-infrared (NIR-II) downshifting luminescence over the physiological range. The luminescence ratio of Tm3+ emission at 1460 nm to Er3+ emission at 1525 nm (Tm3+:3H4 → 3F4; Er3+:4I13/2 → 4I13/2) varies with temperature increase, as well as Yb3+ emission at 980 nm and Ho3+ emission at 1150 nm (Yb3+:2F5/2 → 2F7/2; Ho3+:5I6 → 5I8). The highest relative sensitivity of NaYF4:Tm3+, Er3+@NaYF4@SiO2 and NaYF4:Yb3+, Ho3+@NaYF4:Nd3+@SiO2 aqueous suspension is 0.36% K−1 (at 298 K) and 0.76% K−1 (at 343 K), respectively. The biological tests prove the good biocompatibility and low toxicity of the water-soluble NPs. In vitro tissue penetration experiments verify a much better penetration ability of the synthesized NaYF4:Tm3+, Er3+@NaYF4@SiO2 compared with NaYF4:Yb3+, Ho3+@NaYF4:Nd3+@SiO2 NPs. The excellent physiological luminescent thermometry with favor wave penetration depth provides a promising platform in deep tissue temperature measurement, which is very important in vivo biosensing.