Microfluidics for Biophysical Studies on Artificial Lipid Membranes
A. Yahyazadeh Shourabi (TU Delft - Applied Sciences)
M.E. Aubin-Tam – Promotor (TU Delft - Applied Sciences)
G.H. Koenderink – Promotor (TU Delft - Applied Sciences)
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Abstract
Lipid bilayers are fundamental to cell membranes. This thesis develops novel opto-microfluidic platforms for studying artificial cell membranes, addressing long-standing experimental challenges. Utilizing the developed tools, the work investigates thermomechanical properties of phase-separated membranes, the impact of lipid tail-asymmetry and cholesterol on mechanical properties, electrophysiological measurements on freestanding bilayers, and the effect of azithromycin on bilayers. This research provides new insights into membrane biophysics and advances drug-screening capabilities.