Genome-wide coexpression of steroid receptors in the mouse brain: identifying signaling pathways and functionally coordinated regions

Poster (2015)

Authors

A.M.E.T.A. Mahfouz Pattern Recognition and Bioinformatics - EEMCS
B.P.F. Lelieveldt Pattern Recognition and Bioinformatics - EEMCS
Aldo Grefhorst Erasmus MC
Isabel M. Mol Leiden University Medical Center
Hetty C.M. Sips Leiden University Medical Center
José K. van den Heuvel Leiden University Medical Center
Jenny A. Visser Erasmus MC
M.J.T. Reinders Pattern Recognition and Bioinformatics - EEMCS
Onno C. Meijer Leiden University Medical Center
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Research Group
Pattern Recognition and Bioinformatics (EEMCS) (TU Delft)
Copyright: © 2015 A.M.E.T.A. Mahfouz, B.P.F. Lelieveldt, Aldo Grefhorst, Isabel M. Mol, Hetty C.M. Sips, José K. van den Heuvel, Jenny A. Visser, M.J.T. Reinders, Onno C. Meijer, More Authors
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Published Date

2015

Language

English

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Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Intelligent Systems

Research Group

Pattern Recognition and Bioinformatics

Abstract

Steroid hormones coordinate the activity of many brain regions by binding to nuclear receptors that act as transcription factors. This study uses genome-wide correlation of gene expression in the mouse brain to discover (i) brain regions that respond in a similar manner to particular steroids, (ii) signaling pathways that are used in a steroid receptor and brain region-specific manner, and (iii) potential target genes and relationships between groups of target genes. The data constitute a rich repository for the research community to support further new insights in neuroendocrine relationships and to develop novel ways to manipulate brain activity in research or clinical settings.