Genome-wide coexpression of steroid receptors in the mouse brain: identifying signaling pathways and functionally coordinated regions
Ahmed Mahfouz (TU Delft - Pattern Recognition and Bioinformatics)
Boudewijn Lelieveldt (TU Delft - Pattern Recognition and Bioinformatics)
Aldo Grefhorst (Erasmus MC)
Isabel M. Mol (Leiden University Medical Center)
Hetty C.M. Sips (Leiden University Medical Center)
José K. van den Heuvel (Leiden University Medical Center)
Jenny A. Visser (Erasmus MC)
Marcel Reinders (TU Delft - Pattern Recognition and Bioinformatics)
Onno C. Meijer (Leiden University Medical Center)
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Abstract
Steroid hormones coordinate the activity of many brain regions by binding to nuclear receptors that act as transcription factors. This study uses genome-wide correlation of gene expression in the mouse brain to discover (i) brain regions that respond in a similar manner to particular steroids, (ii) signaling pathways that are used in a steroid receptor and brain region-specific manner, and (iii) potential target genes and relationships between groups of target genes. The data constitute a rich repository for the research community to support further new insights in neuroendocrine relationships and to develop novel ways to manipulate brain activity in research or clinical settings.