M.J.T. Reinders
456 records found
1
Switching from controlled to assisted mechanical ventilation
A multi-center retrospective study (SWITCH)
Switching from controlled to assisted ventilation is crucial in the trajectory of intensive care unit (ICU) stay, but no guidelines exist. We described current practices, analyzed patient characteristics associated with switch success or failure, and explored the f ...
Predicting benefit from adjuvant therapy with corticosteroids in community-acquired pneumonia
A data-driven analysis of randomised trials
C-reactive protein-guided treatment in pneumonia
Charting a personalised approach – Authors’ reply
Two-Step Transfer Learning Improves Deep Learning–Based Drug Response Prediction in Small Datasets
A Case Study of Glioblastoma
The field of forensic DNA analysis has undergone rapid advancements in recent decades. The integration of massively parallel sequencing (MPS) has notably expanded the forensic toolkit, moving beyond identity matching to predicting phenotypic traits and biogeograp ...
The TMEM106B protein is critical for proper functioning of the endolysomal system, which is utilised by all cells to traffic and degrade molecular cargo. Genome-wide association studies identified a haplotype in the TMEM106B gene that is associated with increased r ...
Unraveling how Alzheimer's disease (AD) genetic risk is related to neuropathological heterogeneity, and whether this occurs through specific biological pathways, is a key step toward precision medicine.
Methods
We computed pathway-specific genetic ri ...
Genome-Wide Association Studies (GWAS) have identified 86 SNPs associated with Alzheimer’s disease (AD). GWAS-SNPs are markers of genetic variation in linkage disequilibrium (LD), which may drive the association with AD. One major class of genetic variation are Str ...
PATE
Proximity-Aware Time Series Anomaly Evaluation
Lifestyle factors and metabolomic aging biomarkers
Meta-analysis of cross-sectional and longitudinal associations in three prospective cohorts