M.J.T. Reinders
459 records found
1
Predicting benefit from adjuvant therapy with corticosteroids in community-acquired pneumonia
A data-driven analysis of randomised trials
Genetic testing of common and rare variants in dementia patients from a memory clinic
Dementia-related genetic testing in memory clinic
Many types of dementia have high heritability, which creates opportunities for DNA diagnostics. Clinicians sporadically test for causal genetic variants. However, in addition to causal genetic mutations, an increasing number of both common and rare risk factors are ...
The field of forensic DNA analysis has undergone rapid advancements in recent decades. The integration of massively parallel sequencing (MPS) has notably expanded the forensic toolkit, moving beyond identity matching to predicting phenotypic traits and biogeograp ...
Switching from controlled to assisted mechanical ventilation
A multi-center retrospective study (SWITCH)
Switching from controlled to assisted ventilation is crucial in the trajectory of intensive care unit (ICU) stay, but no guidelines exist. We described current practices, analyzed patient characteristics associated with switch success or failure, and explored the f ...
Two-Step Transfer Learning Improves Deep Learning–Based Drug Response Prediction in Small Datasets
A Case Study of Glioblastoma
C-reactive protein-guided treatment in pneumonia
Charting a personalised approach – Authors’ reply
BADDADAN
Mechanistic modelling of time-series gene module expression
Genome-Wide Association Studies (GWAS) have identified 86 SNPs associated with Alzheimer’s disease (AD). GWAS-SNPs are markers of genetic variation in linkage disequilibrium (LD), which may drive the association with AD. One major class of genetic variation are Str ...
1H-NMR metabolomics and DNA methylation in blood are widely known biomarkers predicting age-related physiological decline and mortality yet exert mutually independent mortality and frailty signals.
Methods
Leveraging multi-omics data in four Dutch popu ...