Construction of correlation networks with explicit time-slices using time-lagged, variable interval standard and partial correlation coefficients

Conference paper (2006)

Authors

MCM Welten External organisation
FJ Verbeek External organisation
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Published Date

2006

Language

Undefined/Unknown

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Abstract

Theconstructionofgeneregulatorymodelsfrommicroarraytime-seriesdatahasreceivedmuchattention.Hereweproposeamethodthatextendsstandardcorrelationnetworkstoincorporateexplicittimeslices.Themethodisappliedtoatime-seriesdatasetofastudyongeneexpressioninthedevelopmentalphaseofzebra¿sh.Resultsshowthatthemethodisabletodistinguishrealrelationsbetweengenesfromthedata.Theserelationsareexplicitlyplacedintime,allowingforabetterunderstandingofgeneregulation.ThemethodanddatanormalisationprocedurehavebeenimplementedusingtheRstatisticallanguageandareavailablefromhttp://zebrafish.liacs.nl/supplements.html.