Theconstructionofgeneregulatorymodelsfrommicroarraytime-seriesdatahasreceivedmuchattention.Hereweproposeamethodthatextendsstandardcorrelationnetworkstoincorporateexplicittimeslices.Themethodisappliedtoatime-seriesdatasetofastudyongeneexpressioninthedevelopmentalphaseofzebra¿sh.Resultsshowthatthemethodisabletodistinguishrealrelationsbetweengenesfromthedata.Theserelationsareexplicitlyplacedintime,allowingforabetterunderstandingofgeneregulation.ThemethodanddatanormalisationprocedurehavebeenimplementedusingtheRstatisticallanguageandareavailablefromhttp://zebrafish.liacs.nl/supplements.html.@en

In the early stages of 3D design, sketches are used to quickly conceptualize ideas and gain insight into problems and possible solutions. Computer-aided design tools are widely used for 3D modeling and design, but their required precision and 2D mouse and screen-based interface inhibit the flow of ideas. A study was conducted to explore the efficiency of hand tracking and virtual reality (VR) for 3D object manipulations in conceptual design. Based on existing research on conceptual design and hand gestures, an intuitive hand-based interaction model is proposed. An experiment on basic 3D manipulation shows that participants using a simple VR and hand-tracking interface prototype have similar performance to those using a traditional mouse and screen interface. For the improvement of gestural conceptual design interfaces, the relevant issues are identified.@en