On CRISPR-controlled Proteases
S.P.B. van Beljouw (TU Delft - BN/Stan Brouns Lab)
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Abstract
This dissertation provides an experimental and conceptual characterization of Craspase, a CRISPR-controlled protease. The array of functionalities inherent to Craspase — including precise protein cleavage, guided RNA recognition, and self-regulatory capabilities — highlights the complexity that can emerge from the endless bacterium-virus coevolution.