Crosslinker-Induced Effects on the Gelation Pathway of a Low Molecular Weight Hydrogel

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Crosslinker-Induced Effects on the Gelation Pathway of a Low Molecular Weight Hydrogel

Journal Article (2017)

Author(s)

Willem E.M. Noteborn (Universiteit Leiden)

Damy N.H. Zwagerman (Universiteit Leiden)

Victorio Saez Talens (Universiteit Leiden)

Chandan Maity (TU Delft - Applied Sciences)

Lars van der Mee (TU Delft - Applied Sciences)

Jos M. Poolman (TU Delft - Applied Sciences)

Serhii Mytnyk (TU Delft - Applied Sciences)

Jan H. van Esch (TU Delft - Applied Sciences)

Rienk Eelkema (TU Delft - Applied Sciences)

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Research Group

ChemE/Advanced Soft Matter

Self-assembly Microstructures Hydrogels Supramolecular materials Crosslinkers

DOI related publication

https://doi.org/10.1002/adma.201603769 Final published version

To reference this document use

https://resolver.tudelft.nl/uuid:85e10a8c-fefc-4e52-b13c-682d7ffc7e67

More Info

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Publication Year

2017

Language

English

Research Group

ChemE/Advanced Soft Matter

Issue number

12

Volume number

29

Article number

1603769

Downloads counter

197

Abstract

Researchers investigated the effect of various (bio)polymeric crosslinkers on the self-assembly process of this reaction-coupled hydrazide-aldehyde gelator into hydrogel materials as a model system. They selected duplex DNA, which acted as a stiff, negatively charged rigid rod below its persistence length ideal for the construction of (nano)materials,[38–40] and compared it against a soft, neutral poly(ethylene glycol) (PEG) polymer of comparable size. Aldehyde moieties were specifically incorporated at the terminal ends of the (bio)polymers to introduce them during the self-assembly of the reaction-coupled network composed another set of (bio)polymers. The researchers also examined the effect of these two crosslinkers on the gelation of the reaction-coupled monomers into hydrogels over several length scales and compared their resultant materials properties.