Crosslinker-Induced Effects on the Gelation Pathway of a Low Molecular Weight Hydrogel

Journal article (2017)

Authors

Willem E.M. Noteborn Universiteit Leiden
Damy N.H. Zwagerman Universiteit Leiden
Victorio Saez Talens Universiteit Leiden
C. Maity ChemE/Advanced Soft Matter - AS
L.H.T. van der Mee ChemE/O&O groep - AS
J.M. Poolman ChemE/Advanced Soft Matter - AS
S. Mytnyk ChemE/Product and Process Engineering - AS
J.H. van Esch ChemE/Advanced Soft Matter - AS
R. Eelkema ChemE/Advanced Soft Matter - AS
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Research Group
ChemE/Advanced Soft Matter (AS) (TU Delft)
Self-assembly Microstructures Hydrogels Supramolecular materials Crosslinkers
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Published Date

2017

Language

English

Reuse Rights

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Faculty

Applied Sciences

Department

ChemE/Chemical Engineering

Research Group

ChemE/Advanced Soft Matter

Abstract

Researchers investigated the effect of various (bio)polymeric crosslinkers on the self-assembly process of this reaction-coupled hydrazide-aldehyde gelator into hydrogel materials as a model system. They selected duplex DNA, which acted as a stiff, negatively charged rigid rod below its persistence length ideal for the construction of (nano)materials,[38–40] and compared it against a soft, neutral poly(ethylene glycol) (PEG) polymer of comparable size. Aldehyde moieties were specifically incorporated at the terminal ends of the (bio)polymers to introduce them during the self-assembly of the reaction-coupled network composed another set of (bio)polymers. The researchers also examined the effect of these two crosslinkers on the gelation of the reaction-coupled monomers into hydrogels over several length scales and compared their resultant materials properties.

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