Cryogenic transmission electron microscopy
the technique of choice for the characterization of polymeric nanocarriers
A. C. Laan (TU Delft - RST/Applied Radiation & Isotopes)
A.G. Denkova (TU Delft - RST/Applied Radiation & Isotopes)
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Abstract
This letter is meant to make scientists aware of the proper application of transmission electron microscopy (TEM) for the assessment of polymeric self-assemblies. Cryogenic (cryo)-TEM should be the method of choice. Here, we show the difference in morphologies observed in the same sample when using cryo-TEM and when using TEM with drying, demonstrating the importance of choosing the proper method.
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