Cryogenic transmission electron microscopy

the technique of choice for the characterization of polymeric nanocarriers

Journal article (2017)

Authors

A.C. Laan RST/Applied Radiation & Isotopes - AS
A.G. Denkova RST/Applied Radiation & Isotopes - AS
Research Group
RST/Applied Radiation & Isotopes (AS) (TU Delft)
Copyright: © 2017 A.C. Laan, A.G. Denkova
DOI
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https://doi.org/10.1186/s13550-017-0290-3
OA-Fund TU Delft
More Info
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Published Date

2017

Language

English

Faculty

Applied Sciences

Department

RST/Radiation, Science and Technology

Research Group

RST/Applied Radiation & Isotopes

Abstract

This letter is meant to make scientists aware of the proper application of transmission electron microscopy (TEM) for the assessment of polymeric self-assemblies. Cryogenic (cryo)-TEM should be the method of choice. Here, we show the difference in morphologies observed in the same sample when using cryo-TEM and when using TEM with drying, demonstrating the importance of choosing the proper method.