KlebPhaCol
a community-driven resource for Klebsiella research identified a novel phage family
Daniela Rothschild-Rodriguez (University of Southampton)
Kai S. Lambon (University of Southampton)
Simran Krishnakant Kushwaha (University of Southampton)
Sofya K. Garushyants (National Institutes of Health)
Moritz Ertelt (Ludwig Maximilians University, Immunology, Infection and Pandemic Research IIP, Munich)
Stan J.J. Brouns (TU Delft - BN/Stan Brouns Lab)
Pieter Jan Haas (University Medical Center Utrecht)
Yan Jiun Lee (Immunology, Infection and Pandemic Research IIP, Munich)
Peter Braun (Immunology, Infection and Pandemic Research IIP, Munich, Ludwig Maximilians University)
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Abstract
The growing threat of multidrug-resistant Klebsiella pneumoniae, coupled with its role in gut colonisation, has intensified the search for new treatments, including bacteriophage therapy. Despite increasing documentation of Klebsiella-targeting phages, clinical applications remain limited, with key phage-bacteria interactions still poorly understood. A major obstacle is fragmented access to well-characterised phage-bacteria pairings, restricting the collective advancement of therapeutic and mechanistic insights. To address this gap, we created the Klebsiella Phage Collection (KlebPhaCol), an open resource comprising 52 phages and 74 Klebsiella isolates, characterised at phenotypic and genomic levels. These phages span six families - including a novel family, Felixviridae, associated with the human gut - and target 20 sequence types (including ST258, ST11, and ST14) and 19 capsular-locus types (including KL1 and KL2), across 6 Klebsiella species. Freely accessible at www.klebphacol.org, KlebPhaCol invites the scientific community to both use and contribute to this resource, fostering collaborative research and a deeper understanding of Klebsiella-phage interactions beyond therapeutic use.
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