Metals in Biotechnology
Cr-Driven Stereoselective Reduction of Conjugated C=C Double Bonds
Marine Rauch (TU Delft - BT/Biocatalysis)
Y. Gallou (TU Delft - BT/Biocatalysis)
L. Delorme (TU Delft - BT/Biocatalysis)
Caroline Paul (TU Delft - BT/Biocatalysis)
IWCE Arends (Universiteit Utrecht)
Frank Hollmann (TU Delft - BT/Biocatalysis)
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Abstract
Elemental metals are shown to be suitable sacrificial electron donors to drive the stereoselective reduction of conjugated C=C double bonds using Old Yellow Enzymes as catalysts. Both direct electron transfer from the metal to the enzyme as well as mediated electron transfer is feasible, although the latter excels by higher reaction rates. The general applicability of this new chemoenzymatic reduction method is demonstrated, and current limitations are outlined.
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