Metals in Biotechnology

Cr-Driven Stereoselective Reduction of Conjugated C=C Double Bonds

Journal article (2019)

Authors

M.C.R. Rauch BT/Biocatalysis - AS
Y. Gallou BT/Biocatalysis - AS
L. Delorme BT/Biocatalysis - AS
C.E. Paul BT/Biocatalysis - AS
I.W.C.E. Arends Universiteit Utrecht
F. Hollmann BT/Biocatalysis - AS
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2019 M.C.R. Rauch, Y. Gallou, L. Delorme, C.E. Paul, I.W.C.E. Arends, F. Hollmann
DOI
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https://doi.org/10.1002/cbic.201900685
Metals Old yellow enzymes Conjugated double bonds Direct regeneration Stereoselective reduction
More Info
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Published Date

2019

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

Elemental metals are shown to be suitable sacrificial electron donors to drive the stereoselective reduction of conjugated C=C double bonds using Old Yellow Enzymes as catalysts. Both direct electron transfer from the metal to the enzyme as well as mediated electron transfer is feasible, although the latter excels by higher reaction rates. The general applicability of this new chemoenzymatic reduction method is demonstrated, and current limitations are outlined.