Influence of Glycyl-L-Glutamic Acid Dipeptide on Calcium Pyrophosphate Dihydrate Crystallization

Journal article (2023)

Authors

S. Polat Complex Fluid Processing - Mechanical, Maritime and Materials Engineering , Marmara University
Q. An Complex Fluid Processing - Mechanical, Maritime and Materials Engineering
H.B. Eral Complex Fluid Processing - Mechanical, Maritime and Materials Engineering
Research Group
Complex Fluid Processing (Mechanical, Maritime and Materials Engineering) (TU Delft)
Copyright: © 2023 S. Polat, Q. An, H.B. Eral
DOI
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https://doi.org/10.1002/ceat.202200628
Morphology Crystallization Calcium pyrophosphate dihydrate Peptides Thermogravimetric analysis
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Published Date

2023

Language

English

Faculty

Mechanical, Maritime and Materials Engineering

Department

Process and Energy

Research Group

Complex Fluid Processing

Abstract

The increasing prevalence of calcium pyrophosphate dihydrate (CPPD) deposition disease, a form of arthritis with high inflammatory potential, has triggered considerable interest in the search for additives to prevent CPPD crystal formation, particularly in the field of biomineralization. In this context, CPPD crystallization in aqueous solution with and without glycine, glutamic acid, or glycyl-L-glutamic acid as crystal-growth modifier was experimentally investigated. The produced crystals were characterized structurally, morphologically, and in terms of their surface charge. In addition, the thermal degradation profiles of CPPD crystals obtained with and without the modifiers were characterized by TGA-FTIR, and the major volatile product was H2O.