Selective Activation of C−H Bonds in a Cascade Process Combining Photochemistry and Biocatalysis
Wuyuan Zhang (TU Delft - Applied Sciences)
Bastien O. Burek (DECHEMA Research Institute)
Elena Fernández-Fueyo (CSIC - Centro de Investigaciones Biologicas (CIB))
Miguel Alcalde (Instituto de Catálisis y Petroleoquímica - CSIC)
Jonathan Z. Bloh (DECHEMA Research Institute)
Frank Hollmann (TU Delft - Applied Sciences)
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Abstract
Selective oxyfunctionalizations of inert C−H bonds can be achieved under mild conditions by using peroxygenases. This approach, however, suffers from the poor robustness of these enzymes in the presence of hydrogen peroxide as the stoichiometric oxidant. Herein, we demonstrate that inorganic photocatalysts such as gold–titanium dioxide efficiently provide H2O2 through the methanol-driven reductive activation of ambient oxygen in amounts that ensure that the enzyme remains highly active and stable. Using this approach, the stereoselective hydroxylation of ethylbenzene to (R)-1-phenylethanol was achieved with high enantioselectivity (>98 % ee) and excellent turnover numbers for the biocatalyst (>71 000).
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