Selective Activation of C−H Bonds in a Cascade Process Combining Photochemistry and Biocatalysis
Wuyuan Zhang (TU Delft - BT/Biocatalysis)
Bastien O. Burek (DECHEMA Research Institute)
E Fernández-Fueyo (CSIC - Centro de Investigaciones Biologicas (CIB))
Miguel Alcalde (Institute of Catalysis, CSIC, Madrid)
Jonathan Z. Bloh (DECHEMA Research Institute)
F Hollmann (TU Delft - BT/Biocatalysis)
More Info
expand_more
Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.
Abstract
Selective oxyfunctionalizations of inert C−H bonds can be achieved under mild conditions by using peroxygenases. This approach, however, suffers from the poor robustness of these enzymes in the presence of hydrogen peroxide as the stoichiometric oxidant. Herein, we demonstrate that inorganic photocatalysts such as gold–titanium dioxide efficiently provide H2O2 through the methanol-driven reductive activation of ambient oxygen in amounts that ensure that the enzyme remains highly active and stable. Using this approach, the stereoselective hydroxylation of ethylbenzene to (R)-1-phenylethanol was achieved with high enantioselectivity (>98 % ee) and excellent turnover numbers for the biocatalyst (>71 000).
help_outline