Low-Impedance PEDOT:PSS MEA Integrated in a Stretchable Organ-on-Chip Device

Journal article (2020)

Authors

Affan K. Waafi Student
N. Gaio BIOND Solutions B.V., Electronic Components, Technology and Materials - EEMCS
W.F. Quiros Solano Electronic Components, Technology and Materials - EEMCS
Paul Dijkstra Philips Innovation Services
Pasqualina M Sarro Electronic Components, Technology and Materials - EEMCS
R. Dekker Philips Research, Electronic Components, Technology and Materials - EEMCS
Research Group
Electronic Components, Technology and Materials (EEMCS) (TU Delft)
Copyright: © 2020 Affan K. Waafi, N. Gaio, W.F. Quiros Solano, Paul Dijkstra, Pasqualina M Sarro, R. Dekker
DOI
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https://doi.org/10.1109/JSEN.2019.2946854
PDMS Microelectrode array PEDOT:PSS Organ-on-chip
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Published Date

2020

Language

English

Reuse Rights

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Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Microelectronics

Research Group

Electronic Components, Technology and Materials

Abstract

We present the first Organ-on-Chip equipped with a low-impedance Poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) MicroElectrode Array (MEA). The novel device allows simultaneous mechanical stimulation with a stretchable PDMS membrane and electrical monitoring via the PEDOT:PSS MEA of multiple in vitro cell cultures. The surface area enhancement and the morphology of the PEDOT:PSS allows an increase of the charge injection per unit area at the electrode-electrolyte interface, resulting in significantly lower electrochemical impedance of the electrodes. In particular, at 1 kHz the fabricated PEDOT-MEA electrodes show a reduction of the overall impedance up to 99.4 and 93.3 % in comparison with benchmark TiN and Pt electrodes. The superior performance of PEDOT:PSS were also confirmed via Cyclic Voltammetry measurement, in which PEDOT:PSS showed a very large capacitive current, compared with the benchmark electrodes both in the forward and the reverse scans. The obtained results confirm the effectiveness of the proposed PEDOT:PSS coating, and introduce this material in the OOC field. Moreover, the quality and morphology of the fabricated PEDOT:PSS based electrodes were assessed via SEM imaging and Raman spectroscopy.