Heat-fueled enzymatic cascade for selective oxyfunctionalization of hydrocarbons
Jaeho Yoon (Korea Advanced Institute of Science and Technology)
Hanhwi Jang (Korea Advanced Institute of Science and Technology)
Min Wook Oh (Hanbat National University, Daejeon)
T. Hilberath (TU Delft - BT/Biocatalysis)
F. Hollmann (TU Delft - BT/Biocatalysis)
Yeon Sik Jung (Korea Advanced Institute of Science and Technology)
Chan Park (Korea Advanced Institute of Science and Technology)
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Abstract
Heat is a fundamental feedstock, where more than 80% of global energy comes from fossil-based heating process. However, it is mostly wasted due to a lack of proper techniques of utilizing the low-quality waste heat (<100 °C). Here we report thermoelectrobiocatalytic chemical conversion systems for heat-fueled, enzyme-catalyzed oxyfunctionalization reactions. Thermoelectric bismuth telluride (Bi2Te3) directly converts low-temperature waste heat into chemical energy in the form of H2O2 near room temperature. The streamlined reaction scheme (e.g., water, heat, enzyme, and thermoelectric material) promotes enantio- and chemo-selective hydroxylation and epoxidation of representative substrates (e.g., ethylbenzene, propylbenzene, tetralin, cyclohexane, cis-β-methylstyrene), achieving a maximum total turnover number of rAaeUPO (TTNrAaeUPO) over 32000. Direct conversion of vehicle exhaust heat into the enantiopure enzymatic product with a rate of 231.4 μM h−1 during urban driving envisions the practical feasibility of thermoelectrobiocatalysis.
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