BacHBerry
BACterial Hosts for production of Bioactive phenolics from bERRY fruits
Alexey Dudnik (Technical University of Denmark (DTU))
A. Filipa Almeida (Universidade Nova de Lisboa, Instituto de Biologia Experimental e Tecnológica)
Ricardo Andrade (Institut National de Recherche en Informatique et en Automatique (INRIA))
Barbara Avila (Pontificia Universidad Católica de Chile)
Pilar Bañados (Pontificia Universidad Católica de Chile)
Diane Barbay (Evolva)
Jean Etienne Bassard (University of Copenhagen)
Mounir Benkoulouche (Evolva)
Michael Bott (Forschungszentrum Jülich)
Adelaide Braga (Biotempo, University of Minho)
Dario Breitel (John Innes Centre)
Rex Brennan (The James Hutton Institute)
Laurent Bulteau (Institut National de Recherche en Informatique et en Automatique (INRIA))
Celine Chanforan (Chr. Hansen Natural Colors A/S)
Inês Costa (Instituto de Biologia Experimental e Tecnológica, Universidade Nova de Lisboa)
Rafael S. Costa (Lisbon Technical University)
Mahdi Doostmohammadi (Lisbon Technical University, The University of Edinburgh)
Nuno Faria (University of Minho, Biotempo)
Chengyong Feng (Chinese Academy of Sciences)
Armando Fernandes (Lisbon Technical University)
Patrícia Ferreira (Biotempo, University of Minho)
Roberto Ferro (Technical University of Denmark (DTU))
Alexandre Foito (The James Hutton Institute)
Sabine Freitag (The James Hutton Institute)
Gonçalo Garcia (Instituto de Biologia Experimental e Tecnológica, Universidade Nova de Lisboa)
Paula Gaspar (Technical University of Denmark (DTU))
Joana Godinho-Pereira (Instituto de Biologia Experimental e Tecnológica, Universidade Nova de Lisboa)
Björn Hamberger (University of Copenhagen)
András Hartmann (Lisbon Technical University)
Harald Heider (Evolva)
Carolina Jardim (Instituto de Biologia Experimental e Tecnológica, Universidade Nova de Lisboa)
Alice Julien-Laferriere (Institut National de Recherche en Informatique et en Automatique (INRIA))
Nicolai Kallscheuer (Forschungszentrum Jülich)
Wolfgang Kerbe (Biofaction KG)
Oscar P. Kuipers (Rijksuniversiteit Groningen)
Shanshan Li (Chinese Academy of Sciences)
Nicola Love (John Innes Centre)
Alberto Marchetti-Spaccamela (Institut National de Recherche en Informatique et en Automatique (INRIA))
Jan Marienhagen (Forschungszentrum Jülich)
Cathie Martin (John Innes Centre)
Arnaud Mary (Institut National de Recherche en Informatique et en Automatique (INRIA))
Vincent Mazurek (Chr. Hansen Natural Colors A/S)
Camillo Meinhart (Biofaction KG)
David Mendez Sevillano (TU Delft - BT/Bioprocess Engineering)
Regina Menezes (Instituto de Biologia Experimental e Tecnológica, Universidade Nova de Lisboa)
Michael Naesby (Evolva)
Morten H.H. Nørholm (Technical University of Denmark (DTU))
Finn T. Okkels (Chr. Hansen Natural Colors A/S)
Joana Oliveira (University of Minho, Biotempo)
Marcel Ottens (TU Delft - BT/Bioprocess Engineering)
Delphine Parrot (Institut National de Recherche en Informatique et en Automatique (INRIA))
Lei Pei (Biofaction KG)
Isabel Rocha (University of Minho, Biotempo)
Rita Rosado-Ramos (Instituto de Biologia Experimental e Tecnológica, Universidade Nova de Lisboa)
Caroline Rousseau (Evolva)
Marie France Sagot (Institut National de Recherche en Informatique et en Automatique (INRIA))
Claudia Nunes Dos Santos (Universidade Nova de Lisboa, Instituto de Biologia Experimental e Tecnológica)
Markus Schmidt (Biofaction KG)
Tatiana Shelenga (N.I.Vavilov Research Institute of Plant Industry)
Louise Shepherd (The James Hutton Institute)
Ana R Silva (Biotempo, University of Minho)
Marcelo Silva (TU Delft - BT/Bioprocess Engineering)
Olivier Simon (Chr. Hansen Natural Colors A/S)
Steen Gustav Stahlhut (Technical University of Denmark (DTU))
Ana Solopova (Rijksuniversiteit Groningen)
Artem Sorokin (N.I.Vavilov Research Institute of Plant Industry)
Derek Stewart (Heriot-Watt University, The James Hutton Institute)
Leen Stougie (Centrum Wiskunde & Informatica (CWI), The University of Edinburgh)
Shang Su (Chinese Academy of Sciences)
Vera Thole (John Innes Centre)
Olga Tikhonova (N.I.Vavilov Research Institute of Plant Industry)
Martin Trick (John Innes Centre)
Philippe Vain (John Innes Centre)
André Veríssimo (Lisbon Technical University)
Ana Vila-Santa (Lisbon Technical University)
Susana Vinga (Lisbon Technical University)
Michael Vogt (Forschungszentrum Jülich)
Liangsheng Wang (Chinese Academy of Sciences)
Lijin Wang (Chinese Academy of Sciences)
Wei Wei (Chinese Academy of Sciences)
Sandra Youssef (Biofaction KG)
Ana Rute Neves (Chr. Hansen Holding A/S)
Jochen Forster (Technical University of Denmark (DTU))
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Abstract
BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.
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