Assessing ultrasonic and optical flow velocimetry in a millifluidic device using oil-in-water emulsions as blood mimicking fluid
Estelle Lu (Sorbonne Université, Institut Pierre-Gilles de Gennes pour la Microfluidique)
Williams Flores Cisternas (Universidad de Valparaíso)
Héloïse Uhl (Institut Pierre-Gilles de Gennes pour la Microfluidique, Sorbonne Université)
Alexandre Chargueraud (Sorbonne Université, Institut Pierre-Gilles de Gennes pour la Microfluidique)
Quentin Grimal (Sorbonne Université)
Guillaume Renaud (TU Delft - Applied Sciences)
Jean Gabriel Minonzio (Universidad de Valparaíso)
Jacques Fattaccioli (Institut Pierre-Gilles de Gennes pour la Microfluidique)
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Abstract
Blood-mimicking fluids (BMFs) play a critical role in ultrasonic imaging and Doppler flow studies by replicating the physical and acoustic properties of blood. This study introduces a novel soybean oil-in-water emulsion as a BMF with particle size akin to red blood cells. Using a millifluidic device, we cross-validated flow profiles through both Doppler velocimetry and optical particle tracking, demonstrating compatibility with theoretical Poiseuille flow models. The millifluidic chip, fabricated via stereolithography, provided an optimized platform for dual optical and ultrasonic assessments. Results showed strong agreement between the two methods across a range of flow rates, affirming the suitability of the emulsion for velocimetry applications. Furthermore, the acoustic properties of soybean oil droplets support their potential as an echogenic and stable alternative to conventional BMFs.
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