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SPAD imagers for super resolution microscopy

Doctoral Thesis (2018)
Author(s)

I. Michel Antolović (TU Delft - (OLD)Applied Quantum Architectures)

Contributor(s)

E. Charbon – Promotor (TU Delft - OLD QCD/Charbon Lab, TU Delft - (OLD)Applied Quantum Architectures)

R.A. Hoebe – Copromotor (Vrije Universiteit Amsterdam, Amsterdam UMC)

Research Group
(OLD)Applied Quantum Architectures
Copyright
© 2018 I.M. Antolović
More Info
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Publication Year
2018
Language
English
Copyright
© 2018 I.M. Antolović
Research Group
(OLD)Applied Quantum Architectures
Bibliographical Note
Ivan Michel Antolović received his B.S. and M.S. degree (cum laude) in electrical engineering and information technology in 2010 and 2012 from University of Zagreb, Croatia. During his master, he started working with Hamamatsu’s multi-pixel photon counters (MPPC), mainly interested in detection of collagen and estrogen autofluorescence. He was awarded "Josip Lončar" Bronze Plaque for the best student of the field electronic and computing engineering. He enrolled to a PhD at the University of Zagreb while working as a firmware designer at Artronic d.o.o. Since 2013, he continued to pursue a PhD degree in single photon avalanche diode (SPAD) imagers at TU Delft. His interests include large format photon counting SPAD imagers and small format time correlated SPAD imagers for microscopy applications like localization super resolution, confocal and fluorescence lifetime. During his PhD, he worked in collaboration with EPFL, Leeuwenhoek Centre for Advanced Microscopy, Macquarie University, Weizmann Institute. He worked with companies like Leica, LFoundry, NXP, TowerJazz and Zeiss. He was awarded PicoQuant Young Investigator Award in 2016 and Else Kooi Award in 2018.@en
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Abstract

The aim of this research is to explore the potential advantages of SPAD imagers used in microscopy. An ideal microscopy detector requires high sensitivity (high quantum efficiency QE or photon detection probability PDP), photon counting operation, low noise (dark current or dark count rate), timing resolution in the order of 100 ps, frame rate higher than 10 fps, a large enough pixel resolution and wavelength resolvability.

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