Functional Convergence of Autonomic and Sensorimotor Processing in the Lateral Cerebellum

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Functional Convergence of Autonomic and Sensorimotor Processing in the Lateral Cerebellum

Journal Article (2020)

Author(s)

Vincenzo Romano (Erasmus MC)

Aoibhinn L. Reddington (Erasmus MC)

Silvia Cazzanelli (Erasmus MC)

Roberta Mazza (Erasmus MC)

Yang Ma (Erasmus MC)

Christos Strydis (Erasmus MC)

Mario Negrello (Erasmus MC)

Laurens W.J. Bosman (Erasmus MC)

Chris I. De Zeeuw (Erasmus MC, Netherlands Institute for Neuroscience)

Plasticity Electrophysiology Optogenetics Respiration Purkinje cells Cerebellum Phase dependent responses Sensorimotor behavior Whisker stimulation Whisking

DOI related publication

https://doi.org/10.1016/j.celrep.2020.107867 Final published version

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https://resolver.tudelft.nl/uuid:d6158cd8-8cb5-499f-a4f1-b544b14c75af

More Info

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Publication Year

2020

Language

English

Issue number

1

Volume number

32

Article number

107867

Downloads counter

253

Abstract

Romano et al. show that cerebellar Purkinje cell activity follows the respiratory rhythm during rest. Triggered by sensory input, Purkinje cells can alter their activity and thereby accelerate the timing of the next inspiration. Concomitantly, they also augment whisker movements, highlighting a coordinating role in aligning autonomic and sensorimotor behaviors.