Electrochemical Amplification in Side-by-Side Attoliter Nanogap Transducers

Journal article (2017)

Authors

H. Zafarani OLD ChemE/Organic Materials and Interfaces
Klaus Mathwig Rijksuniversiteit Groningen
Ernst J. R. Sudhölter OLD ChemE/Organic Materials and Interfaces
L. Rassaei OLD ChemE/Organic Materials and Interfaces
Research Group
OLD ChemE/Organic Materials and Interfaces
Copyright: © 2017 H. Zafarani, Klaus Mathwig, Ernst J. R. Sudhölter, L. Rassaei
DOI
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https://doi.org/10.1021/acssensors.7b00180
Redox cycling Nanofluidics Nanofabrication Electrochemical sensor Generator-collector electrodes Nanogap sensor
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Published Date

23-06-2017

Language

English

Research Group

OLD ChemE/Organic Materials and Interfaces

Abstract

We report a strategy for the fabrication of a new type of electrochemical nanogap transducer. These nanogap devices are based on signal amplification by redox cycling. Using two steps of electron-beam lithography, vertical gold electrodes are fabricated side by side at a 70 nm distance encompassing a 20 attoliter open nanogap volume. We demonstrate a current amplification factor of 2.5 as well as the possibility to detect the signal of only 60 analyte molecules occupying the detection volume. Experimental voltammetry results are compared to calculations from finite element analysis.