Selective Peroxygenase-Catalysed Oxidation of Phenols to Hydroquinones
Hugo Brasselet (TU Delft - BT/Biocatalysis)
Fabian Schmitz (Universität Düsseldorf)
Katja Koschorreck (Universität Düsseldorf)
Vlada B. Urlacher (Universität Düsseldorf)
Frank Hollmann (TU Delft - BT/Biocatalysis)
Thomas Hilberath (TU Delft - BT/Biocatalysis)
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Abstract
An enzymatic method for the selective hydroxylation of phenols using a peroxygenase from Aspergillus brasiliensis (AbrUPO) is reported. A broad range of phenolic starting materials can be selectively transformed into the corresponding hydroquinones. Semi-preparative syntheses of several hydroquinones were realised without further optimization pointing out the applicability of this enzyme as biocatalyst.
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