In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage

Book chapter (2021)

Authors

Junyi Jiang University Hospital Zürich, University of Zürich
S. Lindner University Hospital Zürich, University of Zürich, Swiss Federal Institute of Technology
A. Di Costanzo-Mata University of Zürich, University Hospital Zürich
C. Zhang EKL Equipment - EEMCS
E. Charbon-Iwasaki-Charbon QCD/Sebastiano Lab - QuTech Advanced Research Centre , Quantum Circuit Architectures and Technology - EEMCS , (OLD)Applied Quantum Architectures , Swiss Federal Institute of Technology
M. Wolf University Hospital Zürich, University of Zürich
A. Kalyanov University Hospital Zürich, University of Zürich
Research Group
EKL Equipment (EEMCS) (TU Delft)
Diffuse optical tomography Preterm brain imaging Time-domain near-infrared optical tomography (TD NITOR) Tissue optical properties reconstruction Tissue oxygenation
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Published Date

2021

Language

English

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Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Else Kooi Laboratory

Research Group

EKL Equipment

Abstract

The neonatal brain is a vulnerable organ, and lesions due to hemorrhage and/or ischemia occur frequently in preterm neonates. Even though neuroprotective therapies exist, there is no tool available to detect the ischemic lesions. To address this problem, we have recently designed and built the new time-domain near-infrared optical tomography (TD NIROT) system – Pioneer. Here we present the results of a phantom study of the system performance. We used silicone phantoms to mimic risky situations for brain lesions: hemorrhage and hypoxia. Employing Pioneer, we were able to reconstruct accurately both position and optical properties of these inhomogeneities.